About

This data comes from the Modification of Diet in Renal Disease (MDRD) study from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

The Modification of Diet in Renal Disease (MDRD) study consisted of two randomized clinical trials that investigated whether protein restriction and control of blood pressure had an effect on the progression of chronic kidney disease (CKD). The study tested two hypotheses—that (1) a reduction in dietary protein and phosphorous intake and (2) the maintenance of blood pressure at a level below that usually recommended safely and effectively delays the progression of CKD.

This data is from Study 2, which included patients with relatively advanced renal disease (GFR between 13 and 24 ml/min):

In study 2, 255 patients with GFR of 13 to 24 ml/min/1.73 m2 were randomly assigned to the low-protein diet (0.58 g per kilogram per day) or a very-low-protein diet (0.28 g per kilogram per day) with a keto acid-amino acid supplement, and a usual- or a low-blood-pressure group (same values as those in study 1). The length of follow-up varied from 18-to-45-months, with monthly evaluations of the patients. The primary outcome was the change in GFR rate over time.

Data

`mdrd.csv`

Note

A note on study dropout: Many patients dropped out of the study before completion. Whether or not a patient dropped out is captured in the dropout variable. Reasons for dropout included dialysis, kidney transplant, death, and other medical reasons.

mdrd

Download mdrd.csv

Data Dictionary
variable	description
ptid	Patient identifier
gfr	Glomerular filtration rate in ml/min/1.73 m^2^. A measure of how much blood the kidneys filter per minute
months	Number of months after the start of the study that the measurement was taken.
dietl_normbp	Was the participant assigned to the low-protein, normal-blood pressure diet? (0 = No, 1 = Yes)
dietl_lowbp	Was the participant assigned to the low-protein, low-blood pressure diet? (0 = No, 1 = Yes)
dietk_normbp	Was the participant assigned to the very low-protein, normal-blood pressure diet? (0 = No, 1 = Yes)
dietk_lowbp	Was the participant assigned to the very low-protein, low-blood pressure diet? (0 = No, 1 = Yes)
log_protein	Logarithm of the grams of protein consumed per day.
followupmonths	Number of months until patient follow-up.
dropout	Did the patient drop out of the study? (0 = No, 1 = Yes)

`supp.csv`

Note

This data is simulated and is not from the original MDRD study.

supp

Download supp.csv

Data Dictionary
variable	description
ptid	Patient identifier
sex	Sex
age	Age (years)
height	Height (meters)